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KMID : 0356920080540020225
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Korean Journal of Anesthesiology
2008 Volume.54 No. 2 p.225 ~ p.228
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Negative-pressure Pulmonary Edema by Doxapram-induced Larygospasm
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Suh Jung-Kook
Yeom Jong-Hoon
Bae Dong-Jun
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Abstract
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Doxapram is a peripheral and central respiratory stimulant, producing an increase in tidal volume and a slight increase in respiratory rate.It can temporarily overcome drug-induced respiratory and central nervous system depression, including that seen immediately postoperatively.However, it can also cause side effects, including laryngospasm and vomiting postoperatively.Doxapram-induced laryngospasm causes the increased respiratory efforts to induce more negative pleural pressure, thus causing a negative-pressure pulmonary edema.Therefore, doxapram should not be used if signs of upper airway obstruction are present.
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KEYWORD
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doxapram, laryngospasm, negative pressure pulmonary edema
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